HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 4-amino-3-(3-chlorophenyl)butanoate → 4-(3-Chlorophenyl)pyrrolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 4-amino-3-(3-chlorophenyl)butanoate | HCID 22387061 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 4-(3-Chlorophenyl)pyrrolidin-2-one | HCID 17948941 | 49.2% |
Reaction Steps
In a 500 ml flask fitted with reflux condenser and magnetic stirrer, 135.7 g (561 mmoles) of ethyl 4-amino-3-(3-chlorophenyl)butanoate 378 are dissolved in 200 ml of toluene, and the mixture is refluxed for 30 min. The solution is concentrated to dryness and the residue purified by PrepLC (1 kg SiO2, CH2Cl2/EtOH, 98:2→95:5) to give 54.4 g of pure 379 (49.2%). GC/MS: 197/197 M+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08492416B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-1bd4a17b07c144a794dba2c2db616963 |
| Source note | uspto-grants-2013_07 |