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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 453253Generated: November 3, 2026

methyl 1-[(1S)-2-amino-1-methyl-2-oxoethyl]-5-oxo-3-pyrrolidinecarboxylate → (2S)-2-(4-methoxycarbonyl-2-oxo-1-pyrrolidinyl)butanamide

https://huagongshe.com/reaction/453253

Reaction equation

Participants

RoleNameHCIDCharge
Reactantmethyl 1-[(1S)-2-amino-1-methyl-2-oxoethyl]-5-oxo-3-pyrrolidinecarboxylateHCID 57478738—
Reactantmethyl 1-[(1S)-1-(aminocarbonyl)butyl]-5-oxo-3-pyrrolidinecarboxylateHCID 57478739—
Reactantmethyl 1-{(1S)-1-[(methylamino)carbonyl]propyl}-5-oxo-3-pyrrolidinecarboxylateHCID 66725795—
Product(2S)-2-(4-methoxycarbonyl-2-oxo-1-pyrrolidinyl)butanamideHCID 44367383—

Reaction Steps

Alternatively, methyl 1-[(1S)-2-amino-1-methyl-2-oxoethyl]-5-oxo-3-pyrrolidinecarboxylate, methyl 1-[(1S)-1-(aminocarbonyl)butyl]-5-oxo-3-pyrrolidinecarboxylate, methyl 1-{(1S)-1-[(methylamino)carbonyl]propyl}-5-oxo-3-pyrrolidinecarboxylate, are prepared in similar ways.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08492416B2
Source datasetuspto-grants-2013_07
ORD IDord-f02e6515a11a4a47a4b362014b1c2045
Source noteuspto-grants-2013_07