HCID 44464173, compound → HCID 44464686, compound

Participants

Reaction Steps

A solution of 4-{2-[1-(5-methoxynaphthalen-2-yl)-5-methyl-1H-pyrazol-3-yloxy]ethyl}morpholine (400 mg, 1.08 mmol) in HCl conc. (25 ml) was heated at 90° C. during 7 hrs, cooled down, and evaporated to dryness in a rotavapor. A remaining crude of 4-{2-[1-(5-hydroxynaphthalen-2-yl)-5-methyl-1H-pyrazol-3-yloxy]ethyl}morpholine chlorhydrate was left, which was crystallized in isopropyl alcohol-petroleum ether obtaining 0.32 g (76%) of the product in a solid amorphous form with a melting point m.p.<70° C., and highly hygroscopic.

Provenance & Evidence