HCID 44464434, compound → HCID 44464433, compound

Participants

Reaction Steps

A solution of 4-{2-[1-(7-methoxynaphthalen-2-yl)-5-methyl-1H-pyrazol-3-yloxy]ethyl}morpholine chlorhydrate (1.3 g, 3.24 mmol) in HCl conc. (20 ml) was heated at 90° C. during 6 hrs, it was cooled down and evaporated to dryness in a rotavapor. The remaining crude oil was stirred with ethyl ether and the resulting solid precipitate was filtered; washed with more ethyl ether, and dried yielding 1.2 g (95%) of 4-{2-[1-(7-hydroxynaphthalen-2-yl)-5-methyl-1H-pyrazol-3-yloxy]ethyl}morpholine chlorhydrate in the form of a white solid with a m.p.=103-107° C.

Provenance & Evidence