Hydrochloric Acid → 6-(3-(2-(2-hydroxyethylamino)ethoxy)-5-methyl-1H-pyrazol-1-yl)naphthalen-2-ol hydrochloride

Participants

Reaction Steps

A solution of 2-(2-(1-(6-methoxynaphthalen-2-yl)-5-methyl-1H-pyrazol-3-yloxy)ethylamino)etanol (104 mg, 0.307 mmol) in HCl conc. (4 ml) was heated to reflux during 7 hrs. Then, it was cooled and evaporated to dryness in a rotavapor, the crude residue was washed with ethyl ether and 91 mg of 6-(3-(2-(2-hydroxyethylamino)ethoxy)-5-methyl-1H-pyrazol-1-yl)naphthalen-2-ol hydrochloride were obtained as a solid with a melting point=115-118° C. (yield: 81%)

Provenance & Evidence