HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 453276Generated: October 26, 2026
Methyl 6-chloro-5-nitronicotinate → Methyl 5-amino-6-chloropyridine-3-carboxylate
https://huagongshe.com/reaction/453276
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methyl 6-chloro-5-nitronicotinate | HCID 346961 | — |
| Catalyst | Iron | HCID 23925 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 5-amino-6-chloropyridine-3-carboxylate | HCID 18412438 | 56% |
Reaction Steps
A suspension of methyl 6-chloro-5-nitronicotinate (1 eq), iron powder (5.2 eq), and NH4Cl3 (5.3 eq) in MeOH was heated at 75° C. for 2 h. The mixture was passed through a pad of celite while hot and concentrated in vacuo to give methyl 5-amino-6-chloronicotinate (56% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08492401B2 |
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| Source dataset | uspto-grants-2013_07 |
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| ORD ID | ord-ac6e5532c22546a68a8f5d2ab19e2282 |
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| Source note | uspto-grants-2013_07 |
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