HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → HCID 58551882, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 2-Nitrobenzoyl chloride | HCID 11875 | — |
| Reactant | Methyl 5-amino-6-chloropyridine-3-carboxylate | HCID 18412438 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 58551882 | HCID 58551882 | 73% |
Reaction Steps
Pyridine (1.1 eq) was added to a solution of methyl 5-amino-6-chloronicotinate (1 eq) and 2-nitrobenzoyl chloride (1.2 eq) in CH2Cl2. The mixture was stirred at room temperature for 10 h and concentrated in vacuo. H2O was added and the resultant solid was collected by filtration, rinsed with CH2Cl2 and dried to give methyl 6-chloro-5-(2-nitrobenzamido)nicotinate (73% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08492401B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-9615e9f71e2543498218ac1c298d1a88 |
| Source note | uspto-grants-2013_07 |