HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-Phenyl-5-(pyrrolidin-1-ylmethyl)thiazole-4-carboxylate hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl 2-phenyl-5-(pyrrolidin-1-ylmethyl)thiazole-4-carboxylate | HCID 67425601 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Phenyl-5-(pyrrolidin-1-ylmethyl)thiazole-4-carboxylate hydrochloride | HCID 67425869 | 82% |
Reaction Steps
Concentrated HCl (2.8 ml, 33.9 mmol) was added to a solution of tert-butyl 2-phenyl-5-(pyrrolidin-1-ylmethyl)thiazole-4-carboxylate (2.1 g, 6.1 mmol) in THF (30 ml). The mixture was stirred at rt overnight, and concentrated in vacuo to give 2-phenyl-5-(pyrrolidin-1-ylmethyl)thiazole-4-carboxylate hydrochloride (1.5 g, 82% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08492401B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-dd6ed0a6c7d747779ad1d21e8251e6cb |
| Source note | uspto-grants-2013_07 |