Ethyl 2-benzoylamino-3-oxobutanoate → Ethyl 5-methyl-2-phenyl-1,3-oxazole-4-carboxylate

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Reaction Steps

A solution of ethyl 2-benzamido-3-oxobutanoate (13.0 g, 0.052 mol) in phosphorus oxychloride (100 mL) was heated under reflux for 1.5 h, then cooled and concentrated under reduced pressure to a brown syrup which was dissolved in dichloromethane (250 mL). The solution was washed with water, saturated Na2CO3 and brine successively, then dried over anhydrous Na2SO4 and concentrated to give ethyl 5-methyl-2-phenyloxazole-4-carboxylate as a brown oil (11.0 g, 91% yield).

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