反应详情

A mixture of 5-(3-hydroxypropyl)-2-phenylthiazole-4-carboxylic acid (850 mg, 3.2 mmol) and LiCl (3.2 mmol) in thionyl chloride (10 mL) was heated at reflux for 16 h then concentrated to dryness. The crude product was dissolved in EtOAc, washed with brine, dried (MgSO4), and concentrated under reduced pressure to give 5-(3-chloropropyl)-2-phenylthiazole-4-carbonyl chloride (906 mg, 99% yield).

1. temperaturewas heated
2. temperatureat reflux for 16 h
3. concentrationthen concentrated to dryness
4. dissolutionThe crude product was dissolved in EtOAc
5. washwashed with brine
6. dry with materialdried (MgSO4)
7. concentrationconcentrated under reduced pressure