HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Phenylthiazole-2-carboxylic acid → N-(2-(6-(morpholinomethyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)-4-phenylthiazole-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Phenylthiazole-2-carboxylic acid | HCID 3878539 | — |
| Reactant | 2-(6-(Morpholinomethyl)thiazolo[5,4-b]pyridin-2-yl)aniline | HCID 58551881 | — |
| Solvent | Water | HCID 962 | — |
| Product | N-(2-(6-(morpholinomethyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)-4-phenylthiazole-2-carboxamide | HCID 46244961 | — |
Reaction Steps
The title compound was prepared according to amide synthesis general method A, utilizing 2-(6-(morpholinomethyl)thiazolo[5,4-b]pyridin-2-yl)aniline and 4-phenylthiazole-2-carboxylic acid. The product was isolated by precipitation during the addition of water, triturated with hot methanol and purified by silica gel chromatography (gradient 0 to 10% methanol in CH2Cl2). MS Calcd for C27H23N5O2S2: 513.13. Found (M+H)+ m/z=514.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08492401B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-1688365b2c0a435096bab1ebe938835d |
| Source note | uspto-grants-2013_07 |