HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Methyl-2-phenyl-1,3-oxazole-4-carboxylic acid → 5-methyl-N-(2-(6-(morpholinomethyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)-2-phenyloxazole-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Methyl-2-phenyl-1,3-oxazole-4-carboxylic acid | HCID 318533 | — |
| Reactant | 2-(6-(Morpholinomethyl)thiazolo[5,4-b]pyridin-2-yl)aniline | HCID 58551881 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-methyl-N-(2-(6-(morpholinomethyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)-2-phenyloxazole-4-carboxamide | HCID 46245209 | — |
Reaction Steps
The title compound was prepared according to amide synthesis general method A, utilizing 2-(6-(morpholinomethyl)thiazolo[5,4-b]pyridin-2-yl)aniline and 5-methyl-2-phenyloxazole-4-carboxylic acid. The product was isolated by precipitation by the addition of water, triturated with hot methanol and purified by silica gel chromatography (gradient 0 to 10% methanol in CH2Cl2). MS Calcd for C28H25N5O3S: 511.17. Found (M+H)+ m/z=512.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08492401B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-635b404155814e57998bd6e6228edd01 |
| Source note | uspto-grants-2013_07 |