HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Phenyl-5-(trifluoromethyl)-oxazole-4-carboxylic acid → N-(2-(6-((4-(2-methoxyethyl)piperazin-1-yl)methyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)-2-phenyl-5-(trifluoromethyl)oxazole-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Phenyl-5-(trifluoromethyl)-oxazole-4-carboxylic acid | HCID 2776438 | — |
| Reactant | 2-(6-((4-(2-Methoxyethyl)piperazin-1-yl)methyl)thiazolo[5,4-b]pyridin-2-yl)aniline | HCID 58551870 | — |
| Product | N-(2-(6-((4-(2-methoxyethyl)piperazin-1-yl)methyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)-2-phenyl-5-(trifluoromethyl)oxazole-4-carboxamide | HCID 46245208 | — |
Reaction Steps
The title compound was prepared according to amide synthesis general method B, utilizing 2-(6-((4-(2-methoxyethyl)piperazin-1-yl)methyl)thiazolo[5,4-b]pyridin-2-yl)aniline and 2-phenyl-5-(trifluoromethyl)oxazole-4-carboxylic acid (1.5 eq). The product was filtered from the crude reaction mixture, evaporated with methanol, and purified by silica gel chromatography (gradient 0 to 10% methanol in CH2Cl2) and by prep HPLC. MS Calcd for C31H29F3N6O3S: 622.20. Found (M+H)+ m/z=623.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08492401B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-0a043c69164646249fb9d4c4cc1b6015 |
| Source note | uspto-grants-2013_07 |