HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 453357Generated: October 30, 2026
Diisopropylethylamine → 2-methyl-N-(2-(2-morpholinoethylamino)pyrimidin-5-yl)-5-nitrobenzamide
https://huagongshe.com/reaction/453357
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2-Morpholinoethylamine | HCID 408285 | — |
| Reactant | N-(2-iodopyrimidin-5-yl)-2-methyl-5-nitrobenzamide | HCID 24823735 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 2-methyl-N-(2-(2-morpholinoethylamino)pyrimidin-5-yl)-5-nitrobenzamide | HCID 24823902 | — |
Reaction Steps
N-(2-iodopyrimidin-5-yl)-2-methyl-5-nitrobenzamide (60 mg, 0.156 mmol), 2-morpholinoethanamine (˜200 mg, 1.5 mmol), and DIEA (0.041 mL, 0.234 mmol) were taken up in IPA (2.5 mL) in a 16×100 mm resealable pyrex tube and heated at 70° C. for 4 h. The mixture was concentrated and purified by preparative TLC (2.5% MeOH/CH2Cl2) to afford 2-methyl-N-(2-(2-morpholinoethylamino)pyrimidin-5-yl)-5-nitrobenzamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08492404B2 |
|---|
| Source dataset | uspto-grants-2013_07 |
|---|
| ORD ID | ord-ef4ed4865b71446ea22683e11efed6e7 |
|---|
| Source note | uspto-grants-2013_07 |
|---|
