Isonicotinoyl chloride hydrochloride → N-[5-(4-Chlorobenzylcarbamoyl)-4-methylthiazol-2-yl]isonicotinamide

Participants

Reaction Steps

Following the procedure as described in Example 2, making variations only as required to use isonicotinoyl chloride hydrochloride in place of benzoyl chloride to react with 2-amino-4-methylthiazole-5-carboxylic acid 4-chlorobenzylamide, the title compound was obtained as a white solid in 99% yield; 1H NMR (DMSO-d6, 300 MHz) δ 8.75-8.73 (m, 2H), 7.95-7.93 (m, 2H), 7.34 (s, 2H), 7.31 (s; 2H), 4.86 (s, 2H), 2.54 (s, 3H); MS (ES+) m/z 387.0 (M+1).

Provenance & Evidence