Nicotinoyl chloride → HCID 59369674, compound

Participants

Reaction Steps

Following the procedure as described in Example 2, making variations only as required to use nicotinoyl chloride in place of benzoyl chloride to react with 2-amino-4-methylthiazole-5-carboxylic acid benzylamide, the title compound was obtained as a white solid in 33% yield. m.p. 224-226° C.; 1H NMR (DMSO-d6, 300 MHz) δ 9.17 (d, J=1.5 Hz, 1H), 8.76 (dd, J=1.5, 4.6 Hz, 1H), 8.63 (t, J=5.7 Hz, 1H), 8.40-8.36 (m, 1H), 7.55 (dd, J=4.6, 8.1 Hz, 1H), 7.33-7.19 (m, 5H), 4.38 (d, J=5.7 Hz, 2H), 2.51 (s, 3H); MS (ES+) m/z 353.2 (M+1).

Provenance & Evidence