HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 453547Generated: October 26, 2026
Potassium Carbonate → Tert-butyl 2-(3-cyano-4-(4-(phenethylcarbamoyl)phenoxy)phenyl)acetate
https://huagongshe.com/reaction/453547
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | HCID 45925946 | HCID 45925946 | — |
| Reactant | N-(4-chlorophenethyl)-4-hydroxybenzamide | HCID 60628097 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | Tert-butyl 2-(3-cyano-4-(4-(phenethylcarbamoyl)phenoxy)phenyl)acetate | HCID 68466922 | 50.7% |
Reaction Steps
A mixture of tert-butyl 2-(3-cyano-4-fluorophenyl)acetate (0.122 g), N-(4-chlorophenethyl)-4-hydroxybenzamide (0.150 g), and potassium carbonate (0.086 g) was dissolved in 2 ml of DMSO and stirred at 90° C. After 1 day, the reaction was cooled, loaded onto a silica gel samplet and product eluted with a solvent system gradient of 0.5% methanol/dichloromethane to 5% methanol/dichloromethane to give tert-butyl 2-(3-cyano-4-(4-(phenethylcarbamoyl)phenoxy)phenyl)acetate (0.120 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08492437B2 |
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| Source dataset | uspto-grants-2013_07 |
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| ORD ID | ord-a92cd1c7353643c7afc86b1ec402c392 |
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| Source note | uspto-grants-2013_07 |
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