HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 453549Generated: October 26, 2026
Potassium Carbonate → N-(4-chlorophenethyl)-4-(4-formyl-2-(trifluoromethyl)phenoxy)benzamide
https://huagongshe.com/reaction/453549
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Fluoro-3-(trifluoromethyl)benzaldehyde | HCID 522269 | — |
| Reactant | N-(4-chlorophenethyl)-4-hydroxybenzamide | HCID 60628097 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | N-(4-chlorophenethyl)-4-(4-formyl-2-(trifluoromethyl)phenoxy)benzamide | HCID 86643290 | 92.9% |
Reaction Steps
To a stirred solution of the 4-fluoro-3-(trifluoromethyl)benzaldehyde (177 μL, 1.30 mmol) and N-(4-chlorophenethyl)-4-hydroxybenzamide (359 mg, 1.30 mmol) in DMSO (3 ml) was added K2CO3 (270 mg, 1.95 mmol). The reaction was stirred at 95° C. for 2 hours and then directly purified by silica gel chromatography to give N-(4-chlorophenethyl)-4-(4-formyl-2-(trifluoromethyl)phenoxy)benzamide (0.541 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08492437B2 |
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| Source dataset | uspto-grants-2013_07 |
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| ORD ID | ord-b312c6c86fd64aab9136bd20f4062cc6 |
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| Source note | uspto-grants-2013_07 |
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