Water → ({[2,2-Dimethoxy-1-(nitromethyl)ethyl]thio}methyl)benzene

Participants

Reaction Steps

A solution of (1E)-3,3-dimethoxy-1-nitroprop-1-ene (3.03 g, prepared according to Tetrahedron 2002, 58, 5773-5778), benzyl mercaptan (2.54 mL) and piperidine (0.25 mL) in toluene (20 mL) was stirred at room temperature for 48 hr. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate:hexane=0:100-20:80) to give the title compound (4.78 g, yield 86%) as a yellow oil.

Provenance & Evidence