Ammonium Chloride → Ethyl 3-benzyl-2-methyl-3,4-dihydropyrrolo[2,3-d]imidazole-5-carboxylate

Participants

Reaction Steps

To a solution (50 mL) of sodium ethoxide (5.4 g) in ethanol was added dropwise a mixture of 1-benzyl-2-methyl-1H-imidazole-4-carbaldehyde (3.8 g) and ethyl azidoacetate (10.3 g) under ice-cooling. After the completion of the dropwise addition, the mixture was stirred for 1 hr. Saturated aqueous ammonium chloride solution was added to the reaction mixture, and the mixture was concentrated. The obtained residue was extracted with ethyl acetate. The ethyl acetate layer was is washed with saturated brine, dried (MgSO4) and concentrated. The obtained residue was dissolved in toluene (50 mL), and the mixture was stirred at 110° C. for 2 hr. The reaction mixture was concentrated, and the residue was subjected to silica gel column chromatography to give ethyl 3-benzyl-2-methyl-3,4-dihydropyrrolo[2,3-d]imidazole-5-carboxylate (0.35 g, yield 6.5%) as colorless crystals from a fraction eluted with ethyl acetate-hexane (1:1, volume ratio). melting point 193° C.

Provenance & Evidence