2-(4-bromobutylamino)-1H-indene-1,3(2H)-dione → Methyl 2-(2-bromo-5-(1-(4-(1,3-dioxo-2,3-dihydro-1H-inden-2-ylamino)butyl)-2-phenyl-1H-indole-6-carbonyl)thiophene-3-yl)acetate

Participants

Reaction Steps

To a stirred solution of 453 mg (1 mmol) of methyl-(2-bromo-5-(2-phenyl-1H-indole-6-carbonyl)thiophene-3-yl)acetate in 10 mL of anhydrous CH3CN was added 1.25 g of CsF-Celite under N2, and then followed by 295 mg (1 mmol) 2-(4-bromobutylamino)-1H-indene-1,3(2H)-dione. The resulting mixture was refluxed for 5 h. The mixture was filtered and washed with CH3CN (5 mL×3), the filtrate was evaporated under reduced pressure, and the residue was purified by MPLC (EtOAc/Hex 1:4) to give 280 mg product as a yellow solid (yield 42%).

Provenance & Evidence