2-(4-Chloro-butyl)-2H-[1,2,4]triazine-3,5-dione → HCID 42603370, compound

HRID 453650Notes

Reaction equation

HRID 453650 reaction equation
Cl[CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[C:11](=[O:12])[NH:10][C:9](=[O:13])[CH:8]=[N:7]1.[C:14]([C:18]1[N:23]=[C:22]([N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[CH:21]=[C:20]([CH:30]2[CH2:33][CH2:32][CH2:31]2)[N:19]=1)([CH3:17])([CH3:16])[CH3:15]>>[C:14]([C:18]1[N:23]=[C:22]([N:24]2[CH2:25][CH2:26][N:27]([CH2:2][CH2:3][CH2:4][CH2:5][N:6]3[C:11](=[O:12])[NH:10][C:9](=[O:13])[CH:8]=[N:7]3)[CH2:28][CH2:29]2)[CH:21]=[C:20]([CH:30]2[CH2:33][CH2:32][CH2:31]2)[N:19]=1)([CH3:17])([CH3:15])[CH3:16]

Participants

3

Reactant 2

HCID 158171752-(4-Chloro-butyl)-2H-[1,2,4]triazine-3,5-dioneHCID 666733902-tert-Butyl-4-cyclobutyl-6-(piperazin-1-yl)pyrimidine

Product 1

HCID 42603370HCID 42603370, compound

Procedure

2-{4-[4-(2-tert-Butyl-6-cyclobutyl-pyrimidin-4-yl)-piperazin-1-yl]butyl}-2H-[1,2,4]triazine-3,5-dione was prepared from 2-(4-chloro-butyl)-2H-[1,2,4]triazine-3,5-dione and 2-tert-butyl-4-piperazin-1-yl-6-cyclobutylpyrimidine by analogy to the process described in example 1.

Sources & evidence

ORD record
ord-2d05a020964642e6966641c24ac22dc9
Source dataset
uspto-grants-2013_07
Patent number
US08492540B2

Reaction notes

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