HCID 22349857, compound → HCID 42603340, compound

HRID 453652Notes

Reaction equation

HRID 453652 reaction equation
[Cl:1][CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[C:11](=[O:12])[NH:10][C:9](=[O:13])[C:8]([CH3:14])=[N:7]1.[C:15]([C:19]1[N:24]=[C:23]([N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)[CH:22]=[C:21]([CH2:31][CH2:32][CH3:33])[N:20]=1)([CH3:18])([CH3:17])[CH3:16]>>[ClH:1].[C:15]([C:19]1[N:24]=[C:23]([N:25]2[CH2:30][CH2:29][N:28]([CH2:2][CH2:3][CH2:4][CH2:5][N:6]3[C:11](=[O:12])[NH:10][C:9](=[O:13])[C:8]([CH3:14])=[N:7]3)[CH2:27][CH2:26]2)[CH:22]=[C:21]([CH2:31][CH2:32][CH3:33])[N:20]=1)([CH3:18])([CH3:17])[CH3:16]

Participants

3

Reactant 2

HCID 22349857HCID 22349857, compoundHCID 596144922-(4-Chloro-butyl)-6-methyl-2H-[1,2,4]triazine-3,5-dione

Product 1

HCID 42603340HCID 42603340, compound

Procedure

2-{4-[4-(2-tert-Butyl-6-propyl-pyrimidin-4-yl)-piperazin-1-yl]butyl}-6-methyl-2H-[1,2,4]triazine-3,5-dione hydrochloride was prepared from 2-(4-chloro-butyl)-6-methyl-2H-[1,2,4]triazine-3,5-dione and 2-tert-butyl-4-piperazin-1-yl-6-propyl-pyrimidine by analogy to the process described in example 1.

Sources & evidence

ORD record
ord-0b5210f534834be5b1dd3f8e9f75d453
Source dataset
uspto-grants-2013_07
Patent number
US08492540B2

Reaction notes

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