2-(Chloroacetyl)thiophene → HCID 86660301, compound

Participants

Reaction Steps

(R)-Quinuclidin-3-yl 2-(3-fluorophenyl)-2-(3,4,5-trifluorophenylamino)acetate (I43) (85 mg, 0.21 mmol) and 2-chloro-1-(thiophen-2-yl)ethanone (35.1 mg, 0.22 mmol) were dissolved in acetonitrile (5 ml) and stirred at room temperature for 48 hours. The solvent was evaporated, and the resulting crude compound was purified by flash chromatography (DCM/MeOH=9/1) to obtain (3R)-3-(2-(3-fluorophenyl)-2-(3,4,5-trifluorophenylamino)acetoxy)-1-(2-oxo-2-(thiophen-2-yl)ethyl)-1-azoniabicyclo[2.2.2]octane chloride (70 mg; 59% yield).

Provenance & Evidence