HRID453691
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
CONDITIONS
反应条件
- 温度
- 100 °C
PROCEDURE
实验过程
To a solution of (R)—((R)-quinuclidin-3-yl) 2-phenyl-2-(phenylamino)acetate (diastereomer 1 of I2) (75 mg, 0.22 mmol) in acetonitrile (5 ml), was added 2-bromo-1-(naphthalen-2-yl)ethanone (55.5 mg, 0.22 mmol) and the reaction was stirred at 100° C. for 70 minutes under microwave irradiation (UPLC-MS: complete conversion). The solvent was evaporated and the crude was triturated with i-Pr2O-EtOAc (9/1) to obtain (R)-1-(2-(naphthalen-2-yl)-2-oxoethyl)-3-((R)-2-phenyl-2-(phenylamino)acetoxy)-1-azoniabicyclo[2.2.2]octane bromide (121.9 mg, 93% yield).
WORKUP
后处理
- customThe solvent was evaporated
- customthe crude was triturated with i-Pr2O-EtOAc (9/1)