2-bromo-1-[4-(diethylamino)phenyl]ethanone → HCID 86660304, compound

Participants

Reaction Steps

To a solution of (R)—((R)-quinuclidin-3-yl) 2-phenyl-2-(phenylamino)acetate (diastereomer 1 of I2) (75 mg, 0.22 mmol) in EtOAc (5 ml), was added 2-bromo-1-(4-(diethylamino)phenyl)ethanone (66.3 mg, 0.24 mmol), and the reaction was stirred at room temperature for 15 hours. The solvent was evaporated and the crude was triturated with i-Pr2O to obtain (R)-1-(2-(4-(diethylamino)phenyl)-2-oxoethyl)-3-((R)-2-phenyl-2(phenylamino)acetoxy)-1-azoniabicyclo[2.2.2]octane bromide (129.7 mg, 96% yield).

Provenance & Evidence