N-(2-hydroxyethyl)-N'-(2-benzyloxybenzyl)urea → N-(2-hydroxyethyl)-N'-(2-hydroxybenzyl)urea

Participants

Reaction Steps

59.6 g of N-(2-hydroxyethyl)-N'-(2-benzyloxybenzyl)urea are dissolved in 600 ml of methanol and hydrogenated in the presence of 6 g of Pd/C-catalyst (5%). After 2 hours the hydrogenation ceases. The catalyst is suction-filtered, and the filtrate concentrated by evaporation in vacuo. The residue is recrystallised from 350 ml of ethyl acetate; the pure product melts at 100°-101°.

Provenance & Evidence