2-Bromo-1-(4-hydroxyphenyl)ethanone → HCID 86660310, compound

Participants

Reaction Steps

2-Bromo-1-(4-hydroxyphenyl)ethanone (256 mg, 1.19 mmol) was added to a solution of (R)—((R)-quinuclidin-3-yl) 2-phenyl-2-(phenylamino)acetate (diastereomer 1 of I2) (400 mg, 1.19 mmol) in EtOAc (15 ml). The resulting reaction was stirred at room temperature for 15 hours. The solvent was removed under vacuum, and the residue was triturated with Et2O to obtain (R)-1-(2-(4-hydroxyphenyl)-2-oxoethyl)-3-((R)-2-phenyl-2-(phenylamino)acetoxy)-1-azoniabicyclo[2.2.2]octane bromide (655 mg, 100% yield).

Provenance & Evidence