Ethyl chloroformate → HCID 86660314, compound

Participants

Reaction Steps

Ethyl carbonochloridate (10.5 μl, 0.11 mmol) was added to a solution of (R)-1-(2-(4-aminophenyl)-2-oxoethyl)-3-((R)-2-phenyl-2-(phenylamino)acetoxy)-1-azoniabicyclo[2.2.2]octane bromide (diastereomer 1 of I74) (60 mg, 0.11 mmol) in TEA (15.2 μl, 0.11 mmol) and DCM (2 mL). The reaction mixture was stirred at room temperature overnight. The solvent was evaporated under reduced pressure, and the product was purified by preparative HPLC (eluents: CH3CN/H2O) to obtain (R)-1-(2-(4-(ethoxycarbonylamino)phenyl)-2-oxoethyl)-3-((R)-2-phenyl-2-(phenylamino)acetoxy)-1-azoniabicyclo[2.2.2]octane bromide (14 mg, 20.6% yield).

Provenance & Evidence