2-Chloroacetophenone → HCID 86660316, compound

Participants

Reaction Steps

2-Chloro-1-phenylethanone (I19) (24.4 mg, 0.16 mmol) was added to a solution of 3-(2-oxo-1-phenyl-2-((R)-quinuclidin-3-yloxy)ethylamino)benzoic acid (I5) (60 mg, 0.16 mmol) in acetonitrile (1 ml) and DMF (1 ml). The reaction mixture was stirred at room temperature for 24 hours. The solvent was evaporated, and the residue was purified by preparative HPLC (eluents CH3CN/H2O) to obtain (3R)-3-(2-(3-carboxyphenylamino)-2-phenylacetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane chloride (12 mg, 14.2% yield).

Provenance & Evidence