Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzaldehyde | HCID 240 | — |
| Reactant | 2-Chloroaniline | HCID 7240 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 641194 | HCID 641194 | 81% |
Reaction Steps
98% 2-chloroaniline (781 g; 6 mol) and 98% benzaldehyde (659.6 g; 6 mol) were dissolved in ethanol (832 g), and the solution was boiled under reflux for 8 h (heating apparatus adjusted to 90° C.). Subsequently, the reaction solution was concentrated on a rotary evaporator at 85° C. and 20 mbar and then fractionally distilled through a distillation apparatus. The main fraction distilled over at 142° C. and 1.3 mbar. 1048 g of the product were obtained in 99% purity.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08492558B2 |
|---|
| Source dataset | uspto-grants-2013_07 |
|---|
| ORD ID | ord-9c8aa666687b4989ab9efe6b22149f8a |
|---|
| Source note | uspto-grants-2013_07 |
|---|
