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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 453751Generated: October 31, 2026

(R)-2,3-Dihydrobenzo[1,4]dioxin-2-yl-[(S*)-3-(4-trifluoromethylphenyl)-piperidin-1-yl]methanone → (S*)-1-[(S)-1-(2,3-Dihydrobenzo[1,4]dioxin-2-yl)methyl]-3-(4-trifluoromethylphenyl)piperidine

https://huagongshe.com/reaction/453751

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(R)-2,3-Dihydrobenzo[1,4]dioxin-2-yl-[(S*)-3-(4-trifluoromethylphenyl)-piperidin-1-yl]methanoneHCID 66727248—
SolventTetrahydrofuranHCID 8028—
Product(S*)-1-[(S)-1-(2,3-Dihydrobenzo[1,4]dioxin-2-yl)methyl]-3-(4-trifluoromethylphenyl)piperidineHCID 2517483948.2%

Reaction Steps

(R)-2,3-Dihydrobenzo[1,4]dioxin-2-yl-[(S*)-3-(4-trifluoromethylphenyl)piperidin-1-yl]methanone (13 mg, 0.033 mmol) was treated with BH3 THF according to the above general procedure. Flash chromatography gave 6 mg of the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08492549B2
Source datasetuspto-grants-2013_07
ORD IDord-42fa669b2fa948969c7be5c0d76d0057
Source noteuspto-grants-2013_07