1-(2,3-Dihydrobenzo[1,4]dioxin-2-ylmethyl)-3-methoxymethyl-3-methylpiperidine → 1-(2,3-Dihydrobenzo[1,4]dioxin-2-ylmethyl)-3-(1-methoxy-1-methylethyl)-3-methylpiperidine

HRID 453782Notes

Reaction equation

HRID 453782 reaction equation
O1C2C=CC=CC=2OC[CH:2]1CN1CCCC(COC)(C)C1.[O:22]1[C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][C:26]=2[O:25][CH2:24][CH:23]1[CH2:32][N:33]1[CH2:38][CH2:37][CH2:36][C:35]([C:40]([OH:43])([CH3:42])[CH3:41])([CH3:39])[CH2:34]1>>[O:22]1[C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][C:26]=2[O:25][CH2:24][CH:23]1[CH2:32][N:33]1[CH2:38][CH2:37][CH2:36][C:35]([C:40]([O:43][CH3:2])([CH3:42])[CH3:41])([CH3:39])[CH2:34]1

Participants

3

Reactant 2

HCID 251756611-(2,3-Dihydrobenzo[1,4]dioxin-2-ylmethyl)-3-methoxymethyl-3-methylpiperidineHCID 251756642-[1-(2,3-Dihydrobenzo[1,4]dioxin-2-ylmethyl)-3-methylpiperidin-3-yl]propan-2-ol

Product 1

HCID 251756651-(2,3-Dihydrobenzo[1,4]dioxin-2-ylmethyl)-3-(1-methoxy-1-methylethyl)-3-methylpiperidine

Procedure

Prepared according to the procedure described for 1-(2,3-dihydrobenzo[1,4]dioxin-2-ylmethyl)-3-methoxymethyl-3-methylpiperidine except that 2-[1-(2,3-dihydrobenzo[1,4]dioxin-2-ylmethyl)-3-methylpiperidin-3-yl]propan-2-ol was used instead of [1-(2,3-dihydrobenzo[1,4]dioxin-2-ylmethyl)-3-methylpiperidin-3-yl]methanol.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-dfaca0a6ea524dc29c3962836754fd51
Source dataset
uspto-grants-2013_07
Patent number
US08492549B2

Reaction notes

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