1-(2,3-Dihydrobenzo[1,4]dioxin-2-ylmethyl)-3-ethyl-piperidine-3-carboxylic acid ethyl ester → [1-(2,3-Dihydrobenzo[1,4]dioxin-2-ylmethyl)-3-ethylpiperidin-3-yl]methanol

HRID 453786Notes

Reaction equation

HRID 453786 reaction equation
O1C2C=CC=CC=2OCC1CN1CCCC(CO)(C)C1.C([O:23][C:24]([C:26]1([CH2:43][CH3:44])[CH2:31][CH2:30][CH2:29][N:28]([CH2:32][CH:33]2[O:38][C:37]3[CH:39]=[CH:40][CH:41]=[CH:42][C:36]=3[O:35][CH2:34]2)[CH2:27]1)=O)C>>[O:38]1[C:37]2[CH:39]=[CH:40][CH:41]=[CH:42][C:36]=2[O:35][CH2:34][CH:33]1[CH2:32][N:28]1[CH2:29][CH2:30][CH2:31][C:26]([CH2:24][OH:23])([CH2:43][CH3:44])[CH2:27]1

Participants

3

Reactant 2

HCID 251755011-(2,3-Dihydrobenzo[1,4]dioxin-2-ylmethyl)-3-ethyl-piperidine-3-carboxylic acid ethyl esterHCID 66726912[1-(2,3-Dihydrobenzo[1,4]dioxin-2-ylmethyl)-3-methylpiperidin-3-yl]methanol

Product 1

HCID 25175818[1-(2,3-Dihydrobenzo[1,4]dioxin-2-ylmethyl)-3-ethylpiperidin-3-yl]methanol

Procedure

Prepared according to the procedure described for [1-(2,3-dihydrobenzo[1,4]dioxin-2-ylmethyl)-3-methylpiperidin-3-yl]methanol except that 1-(2,3-dihydrobenzo[1,4]dioxin-2-ylmethyl)-3-ethyl-piperidine-3-carboxylic acid ethyl ester was used instead of 1-(2,3-dihydrobenzo[1,4]dioxin-2-ylmethyl)-3-methylpiperidine-3-carboxylic acid ethyl ester.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-d50e8c5b80554d509b8cedd1c19ad6d0
Source dataset
uspto-grants-2013_07
Patent number
US08492549B2

Reaction notes

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