HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 453805Generated: November 2, 2026
Potassium Carbonate → HCID 25176118, compound
https://huagongshe.com/reaction/453805
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-Hydroxypiperidine | HCID 23293 | — |
| Reactant | 2-Bromomethyl-1,4-benzodioxane | HCID 98333 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 25176118 | HCID 25176118 | — |
Reaction Steps
A mixture of 2-bromomethyl-2,3-dihydrobenzo[1,4]dioxine (2.26 g, 9.88 mmol), piperidin-3-ol (1.0 g, 9.88 mmol) and K2CO3 (6.8 g, 49.43 mmol) in DMF (30 ml) was heated under microwaves at 153° C. for 120 min to give the crude title compound after the usual work-up. The product was purified by column chromatography (DCM/MeOH, 98:2).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08492549B2 |
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| Source dataset | uspto-grants-2013_07 |
|---|
| ORD ID | ord-5f1e3745ee504103a04eeb2fcccd47df |
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| Source note | uspto-grants-2013_07 |
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