HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-4-((2,6-dimethoxyphenoxy)methyl)-2,2-dimethyl-1,3-dioxolane → (R)-3-(2,6-Dimethoxyphenoxy)propane-1,2-diol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-4-((2,6-dimethoxyphenoxy)methyl)-2,2-dimethyl-1,3-dioxolane | HCID 10849486 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (R)-3-(2,6-Dimethoxyphenoxy)propane-1,2-diol | HCID 10799347 | 91.3% |
Reaction Steps
A mixture of (S)-4-((2,6-dimethoxyphenoxy)methyl)-2,2-dimethyl-1,3-dioxolane (2.91 g, 10.85 mmol) and Amberlyst 15® (1.60 g) in methanol (30 ml) were stirred for 5 d. The mixture was filtered and evaporated to dryness to give 2.26 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08492549B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-0c04e14c384d439cb41143aa363ff56e |
| Source note | uspto-grants-2013_07 |