HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 453855Generated: October 30, 2026
Benzoyl Peroxide → Methyl 2-(bromo-methyl)-4-chloro-1-methyl-1H-indole-3-carboxylate
https://huagongshe.com/reaction/453855
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzoyl Peroxide | HCID 7187 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | Methyl 4-chloro-1,2-dimethyl-1H-indole-3-carboxylate | HCID 59473668 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Product | Methyl 2-(bromo-methyl)-4-chloro-1-methyl-1H-indole-3-carboxylate | HCID 59473756 | 48% |
Reaction Steps
Methyl 4-chloro-1,2-dimethyl-1H-indole-3-carboxylate (9.70 mmol, 1.0 equiv.) was dissolved in CCl4 (97 ml), and NBS (9.70 mmol, 1.0 equiv.) and benzoyl peroxide (0.19 mmol, 0.02 equiv.) were added. The mixture was heated for 1 h at 85° C. The resulting succinimide was filtered out, the filtrate was concentrated, and the residue was purified by column chromatography (20% ethyl acetate in hexane). Yield: 48%
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08492559B2 |
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| Source dataset | uspto-grants-2013_07 |
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| ORD ID | ord-41a85795b6ca4f81ae7b4d6bfb8f6e9c |
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| Source note | uspto-grants-2013_07 |
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