反应详情

NBS (40.85 mmol, 1 equiv.) and benzoyl peroxide (10.21 mmol, 0.25 equiv.) were added to a solution of methyl 2,6-dimethylbenzoate (40 mmol, 1 equiv.) in CCL4 (75 ml), and the mixture was heated for 20 min at boiling temperature. The reaction mixture was filtered out over celite and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography (1.5% ethyl acetate/hexane). Yield: 32%

1. temperaturethe mixture was heated for 20 min
2. filtrationThe reaction mixture was filtered out over celite
3. concentrationthe filtrate was concentrated under reduced pressure
4. customThe residue was purified by column chromatography (1.5% ethyl acetate/hexane)