HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetyl chloride → N,N-dimethyl-4-phenylpiperidin-4-amine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | Chloroform methanol | HCID 21584188 | — |
| Reactant | tert-Butyloxycarbonyl-4-(dimethylamino)-4-phenylpiperidine | HCID 57831267 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | N,N-dimethyl-4-phenylpiperidin-4-amine dihydrochloride | HCID 67366566 | — |
Reaction Steps
10 equivalents of acetyl chloride were added to a solution of tert-butyloxycarbonyl-4-(dimethylamino)-4-phenylpiperidine in methanol at 0° C. The reaction course was monitored by thin-layer chromatography (10% MeOH/CHCl3). Once the conversion was complete, the solvent was removed under reduced pressure and the product obtained in the form of a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08492559B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-809c0d9282fe4a69a7afb3578ff2a06b |
| Source note | uspto-grants-2013_07 |