Hydrochloric Acid → 1-(2-Aminoethyl)-N,N-dimethyl-4-(thiophen-2-yl)piperidin-4-amine tris hydrochloride

Participants

Reaction Steps

HCl gas was passed through a solution of 9 g (1 eq.) tert-butyl 2-(4-(dimethylamino)-4-(thiophen-2-yl)piperidin-1-yl)ethylcarbamate in chloroform at 0° C. for ˜30 min. The reaction mixture was then stirred at room temperature for one hour. The reaction course was monitored by thin-layer chromatography (10% MeOH/CHCl3). Once the conversion was complete, the solvent was removed under reduced pressure and 9 g (97%) of product were obtained in the form of a white solid.

Provenance & Evidence