反应详情

WO 2005/102987 provides the reaction of 4-Bromobenzylic bromide and hydrochloride methylester of L-valine methylester in an aprotic solvent and organic or an inorganic base to give methylester of N-(4-bromobenzyl)-L-valine which is deprotected to give N-(4-bromobenzyl)-L-valine. This on acylation with valeryl chloride yields N-(4-bromobenzyl)-N-valeryl-L-valine. Valsartan is prepared by the reaction of N-(4-bromobenzyl)-N-valeryl-L-valine and 2-(1H-tetrazole-5-yl)phenylboronic acid in palladiumtetrakistriphenylphosphine.