Hydrochloric Acid → 2-Amino-4-morpholin-4-ylmethylthiazole-5-carboxylic acid benzylamide

Participants

Reaction Steps

A solution of crude 2-(tert-butoxycarbonylamino)-4-morpholin-4-ylmethylthiazole-5-carboxylic acid benzylamide (0.18 mmol) from the previous step in methanol (5 mL) was treated with hydrochloric acid solution (3 mL, 4 M solution in dioxanes) and the reaxtion mixture was stirred at ambient temperature until the reaction was completed. The mixture was then concentrated and purified by preparative HPLC (acetone/water gradient) to afford 2-amino-4-morpholin-4-ylmethylthiazole-5-carboxylic acid benzylamide (0.030 g).

Provenance & Evidence