HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 7-(Benzyloxy)-4-chloro-6-methoxyquinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 7-Benzyloxy-6-methoxy-3H-quinazolin-4-one | HCID 135404718 | — |
| Product | 7-(Benzyloxy)-4-chloro-6-methoxyquinazoline | HCID 10661998 | — |
Reaction Steps
7-Benzyloxy-6-methoxy-3,4-dihydroquinazolin-4-one (35 g, 124 mmol) was suspended in thionyl chloride (440 ml) and DMF (1.75 ml) and heated at reflux for 4 hours. The thionyl chloride was evaporated under vacuum and the residue azeotroped with toluene three times. The residue was dissolved in NMP (250 ml) to give a solution of 7-benzyloxy-4-chloro-6-methoxyquinazoline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08492560B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-32a290c4c8b0495f87345ad18bc45b69 |
| Source note | uspto-grants-2013_07 |