HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 453994Generated: October 31, 2026
Divinyl sulfone → 4-(3-Hydroxypropyl)thiomorpholine 1,1-Dioxide
https://huagongshe.com/reaction/453994
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Divinyl sulfone | HCID 6496 | — |
| Reactant | 3-Amino-1-propanol | HCID 9086 | — |
| Product | 4-(3-Hydroxypropyl)thiomorpholine 1,1-Dioxide | HCID 11435473 | 90% |
Reaction Steps
A mixture of 3-amino-1-propanol (650 μl, 8.4 mmol) and vinyl sulphone (1 g, 8.4 mmol) was heated at 110° C. for 45 minutes. The mixture was allowed to cool and was purified by column chromatography eluting with methylene chloride/methanol (95/5) to give 3-(1,1-dioxothiomorpholino)-1-propanol (800 mg, 90%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08492560B2 |
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| Source dataset | uspto-grants-2013_07 |
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| ORD ID | ord-792282f4cc3347129e555ff455a202f4 |
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| Source note | uspto-grants-2013_07 |
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