HRID454047

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1cc2c(Cl)ncnc2cc1OCC1CCN(CCS(C)(=O)=O)CC1

HCID22030534

未命名化合物

HCID135451969

未命名化合物

PRODUCTS

生成物

结构：COc1cc2c(Oc3ccc4ccc(C)nc4c3)ncnc2cc1OCC1CCN(CCS(C)(=O)=O)CC1

HCID22030639

未命名化合物

收率 82%

PROCEDURE

实验过程

Using an analogous procedure to that described in Example 42, 4-chloro-6-methoxy-7-(1-(2-methylsulphonylethyl)piperidin-4-ylmethoxy)quinazoline (156 mg, 0.38 mmol), (prepared as described for the starting material in Example 12), was reacted with 7-hydroxy-2-methylquinoline (66 mg, 0.4 mmol), (J. Med. Chem. 1998, 41, 4062), to give 6-methoxy-7-(1-(2-methylsulphonylethyl)piperidin-4-ylmethoxy)-4-(2-methylquinolin-7-yloxy)quinazoline (166 mg, 82%).

WORKUP

后处理

custom(prepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ac1769aeaebd455eaffa7561e0e83a6b
来源数据集: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08492560B2
来源说明: uspto-grants-2013_07

反应 SMILES

Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH2:15][CH:16]3[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][S:24]([CH3:27])(=[O:26])=[O:25])[CH2:18][CH2:17]3)=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][N:3]=1.[OH:28][C:29]1[CH:38]=[C:37]2[C:32]([CH:33]=[CH:34][C:35]([CH3:39])=[N:36]2)=[CH:31][CH:30]=1>>[CH3:13][O:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][C:8]=1[O:14][CH2:15][CH:16]1[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][S:24]([CH3:27])(=[O:26])=[O:25])[CH2:18][CH2:17]1)[N:5]=[CH:4][N:3]=[C:2]2[O:28][C:29]1[CH:38]=[C:37]2[C:32]([CH:33]=[CH:34][C:35]([CH3:39])=[N:36]2)=[CH:31][CH:30]=1