HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazoline → 6-Methoxy-7-(3-pyrrolidin-1-ylpropoxy)4-(2-trifluoromethylindol-5-yloxy)quinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazoline | HCID 11141792 | — |
| Reactant | 2-(Trifluoromethyl)-1h-indol-5-ol | HCID 22030710 | — |
| Product | 6-Methoxy-7-(3-pyrrolidin-1-ylpropoxy)4-(2-trifluoromethylindol-5-yloxy)quinazoline | HCID 22030572 | 71.9% |
Reaction Steps
Using an analogous procedure to that described in Example 44, 4-chloro-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazoline (100 mg, 0.3 mmol), (prepared as described for the starting material in Example 9), was reacted with 5-hydroxy-2-trifluoromethylindole (75 mg, 0.37 mmol), (prepared as described for the starting material in Example 44), to give 6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)-4-(2-trifluoromethylindol-5-yloxy)quinazoline (105 mg, 70%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08492560B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-09af6c3bfa4043668e2cbaade61bdffe |
| Source note | uspto-grants-2013_07 |