HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Hydroxyindole → 4-(Indol-5-yloxy)-6-methoxy-7-(3-piperidinopropoxy)quinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Hydroxyindole | HCID 16054 | — |
| Reactant | 4-Chloro-6-methoxy-7-(3-(piperidin-1-YL)propoxy)quinazoline | HCID 11002191 | — |
| Product | 4-(Indol-5-yloxy)-6-methoxy-7-(3-piperidinopropoxy)quinazoline | HCID 22030732 | 45% |
Reaction Steps
Using an analogous procedure to that described in Example 67, 4-chloro-6-methoxy-7-(3-piperidinopropoxy)quinazoline (100 mg), (prepared as described for the starting material in Example 67), was reacted with 5-hydroxyindole (48 mg, 0.36 mmol) to give 4-(indol-5-yloxy)-6-methoxy-7-(3-piperidinopropoxy)quinazoline (57 mg, 45%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08492560B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-303593c4d770439299460059c65a4648 |
| Source note | uspto-grants-2013_07 |