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HRID454102

反应详情

EQUATION

反应方程式

HRID 454102 的结构方程式

REACTANTS

反应物

2
结构：CCS(=O)(=O)CCCO
HCID12943303

未命名化合物

结构：COc1cc2c(Oc3ccc4[nH]c(C)c(C)c4c3)ncnc2cc1O
HCID135763118

未命名化合物

PRODUCTS

生成物

1
结构：CCS(=O)(=O)CCCOc1cc2ncnc(Oc3ccc4[nH]c(C)c(C)c4c3)c2cc1OC
HCID22030594

4-[(2,3-Dimethyl-1H-indol-5-yl)oxy]-7-[3-(ethylsulfonyl)propoxy]-6-methoxyquinazoline

C24H27N3O5S

收率 57%

PROCEDURE

实验过程

Using an analogous procedure to that described for Example 124, 4-(2,3-dimethylindol-5-yloxy)-7-hydroxy-6-methoxyquinazoline (120 mg, 0.36 mol), (prepared as described for the starting material in Example 91), was reacted with 3-(ethylsulphonyl)-1-propanol (71 mg, 0.46 mol), (prepared as described for the starting material in Example 124), to give 4-(2,3-dimethylindol-5-yloxy)-7-(3-ethylsulphonylpropoxy)-6-methoxyquinazoline (96 mg, 57%).

WORKUP

后处理

  1. custom(prepared
  2. custom(prepared