HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-6-methoxy-7-(3-morpholin-4-ylpropoxy)quinazoline → HCID 22030747, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-6-methoxy-7-(3-morpholin-4-ylpropoxy)quinazoline | HCID 11823941 | — |
| Reactant | 1,2-Dimethyl-1H-indol-5-ol | HCID 12537593 | — |
| Product | HCID 22030747 | HCID 22030747 | 74% |
Reaction Steps
Using an analogous procedure to that described in Example 120 OR 121 PER PP, 4-chloro-6-methoxy-7-(3-morpholinopropoxy)quinazoline (160 mg, 0.48 mmol), (prepared as described for the starting material in Example 1), was reacted with 1,2-dimethyl-5-hydroxyindole (92 mg, 0.57 mol), (Tetrahedron 1994, 50, 13433), to give 4-(1,2-dimethylindol-5-yloxy)-6-methoxy-7-(3-morpholinopropoxy)quinazoline (163 mg, 74%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08492560B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-f9c5918fc0b24dbea0c1615c0f15d356 |
| Source note | uspto-grants-2013_07 |