反应详情

A mixture of 2-amino-4-benzyloxy-5-methoxybenzamide (J. Med. Chem. 1977, vol 20, 146-149, 10 g, 0.04 mol) and Gold's reagent (7.4 g, 0.05 mol) in dioxane (100 ml) was stirred and heated at reflux for 24 hours. Sodium acetate (3.02 g, 0.037 mol) and acetic acid (1.65 ml, 0.029 mol) were added to the reaction mixture and it was heated for a further 3 hours. The mixture was evaporated, water was added to the residue, the solid was filtered off, washed with water and dried. Recrystallisation from acetic acid gave 7-benzyloxy-6-methoxy-3,4-dihydroquinazolin-4-one (8.7 g, 84%).

1. temperatureheated
2. temperatureat reflux for 24 hours
3. temperaturewas heated for a further 3 hours
4. customThe mixture was evaporated
5. additionwater was added to the residue
6. filtrationthe solid was filtered off
7. washwashed with water
8. customdried
9. customRecrystallisation from acetic acid